PSQ02051
FD00555
A disintegrin and metalloproteinase with thrombospondin motifs 9
Q9P2N4
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
269
metalloendopeptidase activity, metallopeptidase activity, zinc ion binding
1935
None
ADAMTS9
9606
endoplasmic reticulum, extracellular matrix, extracellular region, intracellular membrane-bounded organelle
aorta morphogenesis, endothelial cell-matrix adhesion, extracellular matrix organization, glycoprotein catabolic process, heart valve morphogenesis, multicellular organism development, negative regulation of endothelial cell migration, negative regulation of sprouting angiogenesis, protein transport, proteolysis, ventricular cardiac muscle tissue development, vesicle-mediated transport
12514189
269
19:287
EMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKR
PSQ02052
FD00011
Subtilisin-like serine protease Pen ch 18
Q9P8G3
Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Penicillium Penicillium chrysogenum species complex
Penicillium rubens
120
IgE binding, serine-type endopeptidase activity
494
Allergen Pen n 18 , Vacuolar serine protease
None
1108849
None
proteolysis
11964171
120
17:136
SPVAVNSIHNDAAPILSSMTSKDIPDSYIVVFKKHVDPSSASAHQSWLQEVHTAHTGRMELKKRSLFGFDFEAFMGLKHTFHIAGSLLGYAGHFHEDVIEQIRRHPDVDYIEKDSEVRTM
PSQ02053
FD00007
Factor V activator
Q9PT41
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Viperidae Viperinae Macrovipera
Macrovipera lebetina (Levantine viper) (Vipera lebetina)
6
serine-type endopeptidase activity, toxin activity
259
Lebetina viper venom FV activator, Snake venom serine protease
None
8709
extracellular region
None
9920400
6
19:24
QKSSEL
PSQ02054
FND00167
Dermatoxin-B1
Q9PT75
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Hyloidea Hylidae Phyllomedusinae Phyllomedusa
Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)
20
None
77
Dermatoxin
None
8393
extracellular region, membrane, other organism cell membrane
defense response to bacterium
10880984
20
23:42
ESEKREGENEEEQEDDQSEE
PSQ02055
FD00004
Snake venom serine protease BPA
Q9PTU8
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Viperidae Crotalinae Bothrops
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
6
serine-type endopeptidase activity, toxin activity
258
Bothrops protease A
None
8724
extracellular region
None
14580991
6
19:24
QKSSEL
PSQ02056
FD00061
Cholecystokinin
Q9PU29
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Palaeognathae Struthioniformes Struthionidae Struthio
Struthio camelus (Common ostrich)
28, 9
hormone activity
130
None
CCK
8801
axon, extracellular region
axonogenesis, digestion, neuron migration
11072120;11072120
37
21:48, 122:130
QQTAGSHNGNPLAAELEQSLTEHHRHVR, SAEEYEYSS
PSQ02057
FD00061
Cholecystokinin
Q9PU41
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae Phasianinae Gallus
Gallus gallus (Chicken)
28, 9
hormone activity, neuropeptide hormone activity
130
None
CCK
9031
axon, extracellular space
axonogenesis, digestion, neuron migration
11072120;11072120
37
21:48, 122:130
QQPAGSHDGSPVAAELQQSLTEPHRHSR, SAEEYEYSS
PSQ02058
FD00303
Prion-like protein doppel
Q9QUG3
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus
Mus musculus (Mouse)
24
copper ion binding
180
Doppelganger, PrPLP
Prnd
10090
anchored component of external side of plasma membrane
acrosome reaction, cellular copper ion homeostasis, protein homooligomerization, single fertilization
10842180
24
156:179
AALRVAVDQPAMVCLLGFVWFIVK
PSQ02059
FD00029
Group 10 secretory phospholipase A2
Q9QXX3
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus
Mus musculus (Mouse)
11
1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium ion binding, calcium-dependent phospholipase A2 activity, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), phospholipase activity, phospholipid binding
151
Group X secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 10
Pla2g10
10090
acrosomal vesicle, extracellular space, lysosome
arachidonic acid secretion, axon guidance, cellular response to leukemia inhibitory factor, cholesterol homeostasis, defense response to virus, erythrocyte maturation, fertilization, hair follicle morphogenesis, intestinal stem cell homeostasis, low-density lipoprotein particle remodeling, lysophospholipid transport, macrophage activation, negative regulation of cholesterol efflux, negative regulation of cytokine production involved in inflammatory response, negative regulation of DNA-binding transcription factor activity, negative regulation of inflammatory response, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylcholine metabolic process, phosphatidylethanolamine metabolic process, phosphatidylglycerol metabolic process, phosphatidylserine metabolic process, phospholipid metabolic process, platelet activating factor catabolic process, positive regulation of acrosome reaction, positive regulation of arachidonic acid secretion, positive regulation of cellular protein metabolic process, positive regulation of lipid storage, positive regulation of prostaglandin secretion, production of molecular mediator involved in inflammatory response, prostaglandin biosynthetic process, regulation of macrophage activation
11019817
11
18:28
EATRRSHVYKR
PSQ02060
FD00420
Appetite-regulating hormone
Q9QYH7
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus
Rattus norvegicus (Rat)
24
G protein-coupled receptor binding, ghrelin receptor binding, growth hormone-releasing hormone activity, hormone activity, protein tyrosine kinase activator activity
120
Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide
Ghrl
10116
axon, cytoplasm, extracellular region, extracellular space, glutamatergic synapse, postsynapse, Schaffer collateral - CA1 synapse
actin polymerization or depolymerization, activation of MAPK activity, adult feeding behavior, decidualization, dendrite development, energy homeostasis, excitatory postsynaptic potential, G protein-coupled receptor signaling pathway, gastric acid secretion, gastric emptying, negative regulation of apoptotic process, negative regulation of circadian sleep/wake cycle, REM sleep, negative regulation of endothelial cell proliferation, negative regulation of inflammatory response, negative regulation of insulin secretion, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of locomotion, negative regulation of tumor necrosis factor production, positive regulation of adipose tissue development, positive regulation of appetite, positive regulation of bone development, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cold-induced thermogenesis, positive regulation of corticotropin secretion, positive regulation of cortisol secretion, positive regulation of cytosolic calcium ion concentration, positive regulation of eating behavior, positive regulation of feeding behavior, positive regulation of gastric mucosal blood circulation, positive regulation of gastro-intestinal system smooth muscle contraction, positive regulation of growth, positive regulation of growth hormone secretion, positive regulation of growth rate, positive regulation of insulin secretion, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of response to food, positive regulation of small intestinal transit, positive regulation of small intestine smooth muscle contraction, positive regulation of sprouting angiogenesis, positive regulation of synapse assembly, positive regulation of vascular endothelial cell proliferation, postsynaptic modulation of chemical synaptic transmission, regulation of cell population proliferation, regulation of gastric motility, regulation of postsynapse organization, regulation of response to food, regulation of transmission of nerve impulse, response to electrical stimulus, response to estrogen, response to hormone, response to nutrient levels
16284174
24
52:75
ALEGWLHPEDRGQAEEAEEELEIR
PSQ02061
FD00247
Peptidylarginine deiminase
Q9RQJ2
Bacteria Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas
Porphyromonas gingivalis (strain ATCC BAA-308
20
protein-arginine deiminase activity
556
None
None
242619
extracellular region
putrescine biosynthetic process
10377098
20
24:43
QTQMQADRTNGQFATEEMQR
PSQ02062
FD00342
Probable subtilase-type serine protease DR_A0283
Q9RYM8
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus
Deinococcus radiodurans (strain ATCC 13939 , 4051
126
serine-type endopeptidase activity
728
None
None
243230
extracellular region
None
15249204
126
23:148
ACGQPQTSPQSPAASAPSVAVPRTHALDIDPAQVVTTKNGDMYVRNQLVVNLRGHSADALADQLGGRVLDQLPELDVALIELPQGKDARSVGVALMREGQVLYAAAQTVQRQIEPVRTAQDQLGAQ
PSQ02063
FND00224
Uncharacterized protein DR_A0282
Q9RYM9
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus
Deinococcus radiodurans (strain ATCC 13939 , 4051
212
None
504
None
None
243230
None
None
15249204
212
1:212
MFMKSKAAGSEFDGAVAKDNVNTRLKIAQFMSADPNATADVPQLKLETPTAFKANGEVDTWGPLGSGTAFNDVVNVRAYSVKNSDQPRVMRYFLFSLVNIDKDGTWSDVRPAAGLYEQDPGYVTPGVDPNNKGQGQDSGLVSLDATGLEGDVYLQVVGLDFNYNRVAYLVPLKLNRTKAASEVVAPTNVRAIAYTLSTRIDYLYKTQDPVLD
PSQ02064
FND00294
Silaffin-1
Q9SE35
Eukaryota Sar Stramenopiles Ochrophyta Bacillariophyta Bacillariophyceae Bacillariophycidae Bacillariales Bacillariaceae Cylindrotheca
Cylindrotheca fusiformis (Marine diatom)
88
None
265
natSil-1
SIL1
2853
None
biomineral tissue development
10550045
88
20:107
QSIADLAAANLSTEDSKSAQLISADSSDDASDSSVESVDAASSDVSGSSVESVDVSGSSLESVDVSGSSLESVDDSSEDSEEEELRIL
PSQ02065
FD00361
Polyneuridine-aldehyde esterase
Q9SE93
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Rauvolfioideae Vinceae Rauvolfiinae Rauvolfia
Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum)
6
polyneuridine-aldehyde esterase activity
264
Polyneuridine aldehyde esterase
PNAE
4060
None
indole alkaloid metabolic process
10691977
6
1:6
MHSAAN
PSQ02066
FND00061
Arabinogalactan protein 13
Q9STQ3
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis
Arabidopsis thaliana (Mouse-ear cress)
22
None
60
Arabinogalactan peptide 13
AGP13
3702
anchored component of membrane, plasma membrane
None
11006345, 15322080
22
38:59
DASLAIPAFFASVATLAFGFLF
PSQ02067
FD00054
Endonuclease 1
Q9SXA6
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis
Arabidopsis thaliana (Mouse-ear cress)
19
double-stranded DNA exodeoxyribonuclease activity, endonuclease activity, endoribonuclease activity, endoribonuclease activity, producing 5, metal ion binding, nucleic acid binding, single-stranded DNA endodeoxyribonuclease activity, T/G mismatch-specific endonuclease activity
305
Bifunctional nuclease I , Deoxyribonuclease ENDO1 , Single-stranded-nucleate endonuclease ENDO1
ENDO1
3702
None
DNA catabolic process, floral organ senescence, leaf senescence, RNA phosphodiester bond hydrolysis, endonucleolytic
23620482
19
287:305
MILNRVFSDDHAIAGVAAT
PSQ02068
FD00411
A disintegrin and metalloproteinase with thrombospondin motifs 4
Q9TT93
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos
Bos taurus (Bovine)
161
metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity
840
ADMP-1, Aggrecanase-1
ADAMTS4
9913
extracellular matrix, extracellular region
extracellular matrix organization
10356395
161
52:212
ASPLPREEEIVFPEKLNGSVLPGLGAPARLLYRLPAFGETLLLELEKDPGVQVEGLTVQYLGRAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGTELHIQPLEGGAPNSAGGPGAHILRRKSPVSGQGPMCNVKAPPGKPSPSPRRAKR
PSQ02069
FD00438
Apelin
Q9TUI9
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos
Bos taurus (Bovine)
19
apelin receptor binding, hormone activity
77
APJ endogenous ligand
APLN
9913
extracellular region, extracellular space
angiogenesis, apelin receptor signaling pathway, coronary vasculature development, drinking behavior, gastrulation, negative regulation of blood pressure, positive regulation of G protein-coupled receptor internalization, positive regulation of heart contraction
9792798
19
23:41
GPLLQTSDGKEMEEGTIRY
PSQ02070
FD00003
Delta-conotoxin GmVIA
Q9TWM7
Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Conoidea Conidae Conus Cylinder
Conus gloriamaris (Glory-of-the-Seas cone)
26
sodium channel inhibitor activity, toxin activity
77
None
None
37336
extracellular region
pathogenesis
7918355
26
23:48
DDSGNGMEILFPKAGHEMENLEVSNR
PSQ02071
FD00292
Serine-repeat antigen protein 5
Q9TY95
Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida Plasmodiidae Plasmodium Plasmodium (Laverania)
Plasmodium falciparum (isolate 3D7)
44
cysteine-type endopeptidase activity, cysteine-type peptidase activity, kinase binding, peptidase activity, serine-type peptidase activity
997
111 kDa antigen, Serine protease SERA5 , p126
SERA5
36329
extracellular space, lysosome, plasma membrane, symbiont-containing vacuolar space, symbiont-containing vacuole
exit from host cell, proteolysis, proteolysis involved in cellular protein catabolic process, regulation of immune response
24769454, 25599609
44
843:886
KASPEFYHNLYFKNFNVGKKNLFSEKEDNENNKKLGNNYIIFGQ
PSQ02072
FD00120
Putative inactive caspase B
Q9TZP5
Eukaryota Metazoa Ecdysozoa Nematoda Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis
Caenorhabditis elegans
8
caspase binding, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, zymogen binding
263
None
csp-2
6239
cytoplasm, protease inhibitor complex
activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, execution phase of apoptosis, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of apoptotic process, positive regulation of apoptotic process involved in development, positive regulation of brood size, positive regulation of fertilization
9857046
8
1:8
MMCEDASD
PSQ02073
FD00091
DELTA-stichotoxin-Hmg2a
Q9U6X1
Eukaryota Metazoa Cnidaria Anthozoa Hexacorallia Actiniaria Stichodactylidae Heteractis
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
15
channel activity, toxin activity
211
Cytolysin III, Cytolysin-3, HMg III , Magnificalysin III
None
38281
extracellular region, nematocyst, other organism cell membrane, pore complex
cation transport, hemolysis in other organism involved in symbiotic interaction, pore complex assembly
10719170
15
20:34
VPSREELEDQKEYKR
PSQ02074
FD00014
Conotoxin p5a
Q9U6Z6
Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Conoidea Conidae Conus Chelyconus
Conus purpurascens (Purple cone)
31
toxin activity
63
P5, PVA
None
41690
extracellular region
None
10521453
31
20:50
VDAHPKTKDDMPLASFHDNAKGTLQRFWKKR
PSQ02075
FD00419
Golgi-associated kinase 1A
Q9UFP1
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
90, 139
None
575
Protein FAM198A
GASK1A
9606
caveola, endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle
None
30188967;30188967
229
30:119, 437:575
VTRFPPQRPSAGPDPGPMEPQGVTGAPATHIRQALSSSRRQRARNMGFWRSRALPRNSILVCAEEQGHRARVDRSRESPGGDLRHPGRVR, RYCCGFEPEPSDPCVEERLREKCQNPAELRLVHILVRSSDPSHLVYIDNAGNLQHPEDKLNFRLLEGIDGFPESAVKVLASGCLQNMLLKSLQMDPVFWESQGGAQGLKQVLQTLEQRGQVLLGHIQKHNLTLFRDEDP
PSQ02076
FD00209
A disintegrin and metalloproteinase with thrombospondin motifs 7
Q9UKP4
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
209
metal ion binding, metalloendopeptidase activity, metallopeptidase activity
1686
COMPase
ADAMTS7
9606
endoplasmic reticulum lumen, extracellular matrix, extracellular region
cellular response to BMP stimulus, cellular response to interleukin-1, cellular response to tumor necrosis factor, extracellular matrix organization, negative regulation of chondrocyte differentiation, proteolysis involved in cellular protein catabolic process
15192113
209
28:236
APGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQR
PSQ02077
FD00507
A disintegrin and metalloproteinase with thrombospondin motifs 5
Q9UNA0
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
245
endopeptidase activity, extracellular matrix binding, heparin binding, integrin binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding
930
A disintegrin and metalloproteinase with thrombospondin motifs 11, ADMP-2, Aggrecanase-2
ADAMTS5
9606
collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular space
defense response to bacterium, extracellular matrix disassembly, extracellular matrix organization, myoblast fusion, negative regulation of cold-induced thermogenesis, proteolysis, tooth eruption
18992360
245
17:261
LAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRR
PSQ02078
FD00027
Versatile peroxidase VPL1
Q9UR19
Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Pleurotaceae Pleurotus
Pleurotus eryngii (Boletus of the steppes)
8
23:30
361
Versatile liquid phase peroxidase 1
vpl1
5323
extracellular region
hydrogen peroxide catabolic process, lignin catabolic process, response to oxidative stress
9987124
8
23:30
AVPLVQKR
PSQ02079
FD00011
Subtilisin-like serine protease Pen ch 13
Q9URR2
Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Penicillium Penicillium chrysogenum species complex
Penicillium rubens
96
serine-type endopeptidase activity
397
Alkaline serine protease , Allergen Pen n 13
None
1108849
extracellular space
proteolysis
10694469
96
20:115
GTLLTASNTDAVIPSSYIVVMNDDVSTAEFSTHREWATNVHARLSRRKNGETGPGKHFEINGLKGYTASFDENTAKDIANDPAVKYIEPDMIVNAT
PSQ02080
FD00027
Versatile peroxidase VPS1
Q9UVP6
Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Pleurotaceae Pleurotus
Pleurotus eryngii (Boletus of the steppes)
11
21:31
370
Versatile solid phase peroxidase 1
vps1
5323
extracellular region
hydrogen peroxide catabolic process, lignin catabolic process, response to oxidative stress
10187820, 11004397
11
21:31
ESPTHRCLNKR
PSQ02081
FD00249
Serine protease 7
Q9V3Z2
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
109
metal ion binding, serine-type endopeptidase activity
391
Melanization protease 2
Sp7
7227
extracellular region, extracellular space
defense response to Gram-positive bacterium, melanization defense response, positive regulation of melanization defense response, proteolysis
24260243
109
28:136
QGSCRNPNQKQGQCLSIYDCQSLLSVIQQSYVSPEDRTFLRNSQCLDGVGRQPYVCCTSDRSFGSQEATSAAPPPTTTSSSSRGQDGQAGLGNLLPSPPKCGPHSFSNK
PSQ02082
FND00358
Neuropeptide F
Q9VET0
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
6, 37
G protein-coupled receptor binding, neuropeptide F receptor binding, neuropeptide hormone activity
102
dNPF
NPF
7227
extracellular region
circadian behavior, circadian rhythm, digestion, endocrine signaling, G protein-coupled receptor signaling pathway, larval feeding behavior, larval foraging behavior, larval locomotory behavior, locomotor rhythm, male courtship behavior, neuropeptide signaling pathway, olfactory behavior, regulation of response to food, response to odorant, social behavior
10499420;10499420
43
27:32, 66:102
SNSRPP, GSLMDILRNHEMDNINLGKNANNGGEFARGFNEEEIF
PSQ02083
FD00189
Serine protease HTRA2
Q9VFJ3
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
57
peptidase activity, serine-type endopeptidase activity
422
High temperature requirement protein A2 , Omi stress-regulated endoprotease
HtrA2
7227
cytosol, integral component of membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, Nebenkern
apoptotic process, ectopic germ cell programmed cell death, mitochondrion organization, positive regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity, regulation of apoptotic process, spermatogenesis
18259196
57
18:74
ASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLG
PSQ02084
FND00209
Protein hugin
Q9VG55
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
95, 7
ecdysis-triggering hormone activity, hormone activity, myostimulatory hormone activity, neuropeptide receptor binding, signaling receptor binding
191
None
Hug
7227
extracellular region, extracellular space
ecdysis, chitin-based cuticle, larval feeding behavior, neuropeptide signaling pathway
12204246;12204246
102
25:119, 185:191
KSLQGTSKLDLGNHISAGSARGSLSPASPALSEARQKRAMGDYKELTDIIDELEENSLAQKASATMQVAAMPPQGQEFDLDTMPPLTYYLLLQKL, AQVCGGD
PSQ02085
FND00197
Tachykinins
Q9VGE8
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
23
neuropeptide hormone activity, neurotransmitter transmembrane transporter activity, signaling receptor binding, tachykinin receptor binding
289
dTk
Tk
7227
extracellular space
adult walking behavior, inter-male aggressive behavior, lipid metabolic process, neuropeptide signaling pathway, positive regulation of hindgut contraction, positive regulation of sensory perception of pain, response to pheromone, sensory perception of smell, tachykinin receptor signaling pathway
10801863
23
25:47
ADTETESSGSPLTPGAEEPRRVV
PSQ02086
FD00141
Protein spaetzle 5
Q9VZX1
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
255
growth factor activity, receptor ligand activity, Toll binding
387
Neurotrophic factor 2 , Protein spatzle 5
spz5
7227
extracellular region, extracellular space
axon guidance, central nervous system formation, innate immune response, motor neuron axon guidance, nervous system development, positive regulation of antimicrobial peptide production, regulation of cell death, regulation of neuronal synaptic plasticity in response to neurotrophin, regulation of synaptic plasticity, regulation of Toll signaling pathway, Toll signaling pathway
23892553
255
30:284
HSSPPPCGLYGAPPCQFLPAPPGQTPTCARPGKTYCEHADNYPTYLIKSLVRKWGYEAATLLVDETWEDFAAVAWHDTPVFYDPKSIFPPRDPAAQDFNGYSYQTPFGGNPQRPSGGGNPLFVSNPSTEAPTYLLYTSSGGGHRSGHRYNSQGGGTSSSGGHLYINQSDKSTPYNATLWLKRLVRDLSRKQRQPDEVQAEVVEPVNEQTEEAEEQDNPAEDHPQSKRDVSLNMDLLDIVGVEAPNPLKKRSRTKR
PSQ02087
FD00029
Acidic phospholipase A2 2
Q9W7J3
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Acanthophiinae Pseudonaja
Pseudonaja textilis (Eastern brown snake)
8
calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity
154
Phosphatidylcholine 2-acylhydrolase, Pt-PLA2
None
8673
extracellular region
arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process
14678780
8
20:27
ARIPPLPL
PSQ02088
FD00010
Acidic phospholipase A2 1
Q9W7J4
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Elapidae Acanthophiinae Pseudonaja
Pseudonaja textilis (Eastern brown snake)
8
calcium ion binding, phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), toxin activity
154
Phosphatidylcholine 2-acylhydrolase, Pt-PLA1
None
8673
extracellular region
arachidonic acid secretion, lipid catabolic process, phospholipid metabolic process
14678780
8
20:27
ARIPPLPL
PSQ02089
FD00564
Microcin J25
Q9X2V7
Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia
Escherichia coli
37
None
60
Class II lasso peptide , Ribosomally synthesized and post-translationally modified peptide
mcjA
562
extracellular region
cytolysis, defense response to bacterium
10092860
37
1:37
MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTK
PSQ02090
FD00544
Collagenase ColG
Q9X721
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Hathewaya
Hathewaya histolytica (Clostridium histolyticum)
65
calcium ion binding, collagen binding, endopeptidase activity, metalloendopeptidase activity, serine-type endopeptidase activity, tripeptidase activity, zinc ion binding
1118
Class I collagenase , Gelatinase ColG , Microbial collagenase
colG
1498
extracellular region
collagen metabolic process, pathogenesis
9922257
65
46:110
KPIENTNDTSIKNVEKLRNAPNEENSKKVEDSKNDKVEHVKNIEEAKVEQVAPEVKSKSTLRSAS
PSQ02091
FD00412
Procardosin-A
Q9XFX3
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids campanulids Asterales Asteraceae Carduoideae Cardueae Carduinae Cynara
Cynara cardunculus (Cardoon)
44, 105
aspartic-type endopeptidase activity
504
None
cardA
4265
cell wall, endoplasmic reticulum, extracellular region, membrane, protein storage vacuole
lipid metabolic process
9692911;9692911
149
25:68, 310:414
VSDDGLIRIGLKKRKVDRIDQLRGRRALMEGNARKDFGFRGTVR, GVMNQQCKTVVSRYGRDIIEMLRSKIQPDKICSHMKLCTFDGARDVSSIIESVVDKNNDKSSGGIHDEMCTFCEMAVVWMQNEIKQSETEDNIINYANELCEHLS
PSQ02092
FD00487
Procardosin-B
Q9XFX4
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids campanulids Asterales Asteraceae Carduoideae Cardueae Carduinae Cynara
Cynara cardunculus (Cardoon)
46
aspartic-type endopeptidase activity
506
None
cardB
4265
cell wall, endoplasmic reticulum, extracellular region, membrane, protein storage vacuole
lipid metabolic process
8654427
46
25:70
VSNGGLLRVGLKKRKVDRLDQLRAHGVHMLGNARKDFGFRRTLSDS
PSQ02093
FD00502
Caspase Dronc
Q9XYF4
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
134
CARD domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, endopeptidase activity, protein homodimerization activity
450
NEDD2-like caspase
Dronc
7227
apoptosome, cytoplasm, nucleus, plasma membrane
activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, central nervous system development, chaeta development, compound eye development, dendrite morphogenesis, determination of adult lifespan, ectopic germ cell programmed cell death, embryonic development via the syncytial blastoderm, execution phase of apoptosis, head involution, hemocyte development, melanization defense response, metamorphosis, negative regulation of cell population proliferation, neuron remodeling, nurse cell apoptotic process, positive regulation of apoptotic process, positive regulation of compound eye retinal cell programmed cell death, positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, positive regulation of necrotic cell death, programmed cell death, programmed cell death involved in cell development, protein autoprocessing, regulation of autophagy, regulation of cell death, salivary gland histolysis, sperm individualization, zymogen activation
10200258
134
1:134
MQPPELEIGMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIV
PSQ02094
FND00322
Contulakin-G
Q9XYR5
Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Conoidea Conidae Conus Gastridium
Conus geographus (Geography cone) (Nubecula geographus)
28
toxin activity
76
CGX-1160
None
6491
extracellular region
None
10318778
28
23:50
GKLNDVIRGLVPDDITPQLILGSLISRR
PSQ02095
FD00003
Delta-conotoxin SVIE
Q9XZK5
Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Conoidea Conidae Conus Pionoconus
Conus striatus (Striated cone)
29
sodium channel inhibitor activity, toxin activity
82
Omega-conotoxin SO-6, Omega-conotoxin-4
SO6
6493
extracellular region
pathogenesis
11683628
29
23:51
DDSRYGLKNLFPKARHEMKNPEASKLNKR
PSQ02096
FND00232
BmK-YA precursor
Q9Y0X6
Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Mesobuthus
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
11, 56, 34, 34
opioid peptide activity, toxin activity
200
None
None
34649
extracellular region
None
22792309;22792309;22792309;22792309
135
24:34, 45:100, 111:144, 155:188
DKERQDWIPSD, SDEERQDWIPSDYGGHMNPAGRSDEERQDWIPSDYGGHMNPAGRSNEERQDWIPSD, SDEERQDWIPSDYGGHMNPAGRSNEERQDWIPSD, SDEERQDWIPSDYGGHMNPAGRSDEERQDWIPSD
PSQ02097
FD00448
Heparanase
Q9Y251
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
48
beta-glucuronidase activity, heparanase activity, syndecan binding
543
Endo-glucoronidase, Heparanase-1
HPSE
9606
extracellular matrix, extracellular region, heparanase complex, intracellular membrane-bounded organelle, lysosomal lumen, lysosomal membrane, lysosome, membrane raft, nucleoplasm, nucleus, specific granule lumen
angiogenesis involved in wound healing, cell-matrix adhesion, glycosaminoglycan catabolic process, heparan sulfate proteoglycan catabolic process, neutrophil degranulation, positive regulation of blood coagulation, positive regulation of hair follicle development, positive regulation of osteoblast proliferation, positive regulation of protein kinase B signaling, positive regulation of vascular endothelial growth factor production, proteoglycan metabolic process, regulation of hair follicle development, vascular wound healing
10395326, 10446189, 12713442
48
110:157
STFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQ
PSQ02098
FD00126
Beta-secretase 2
Q9Y5Z0
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
42
aspartic-type endopeptidase activity
518
Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase
BACE2
9606
dense core granule, endoplasmic reticulum, endosome, Golgi apparatus, integral component of membrane, membrane, plasma membrane, trans-Golgi network
amyloid-beta metabolic process, astrocyte activation, glucose homeostasis, membrane protein ectodomain proteolysis, negative regulation of amyloid precursor protein biosynthetic process, peptide hormone processing, proteolysis
10591213, 11083922, 11423558, 16305800, 16816112
42
21:62
APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLAL
PSQ02099
FD00500
Carboxypeptidase Q
Q9Y646
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
24
carboxypeptidase activity, metal ion binding, metallodipeptidase activity, protein homodimerization activity
479
Lysosomal dipeptidase, Plasma glutamate carboxypeptidase
CPQ
9606
cytoplasm, endoplasmic reticulum, extracellular exosome, extracellular space, Golgi apparatus, intracellular membrane-bounded organelle, lysosome
peptide catabolic process, proteolysis, thyroid hormone generation, tissue regeneration
10206990, 12675526
24
21:44
KAICKNGISKRTFEEIKEEIASCG
PSQ02100
FD00185
Tolloid-like protein 2
Q9Y6L7
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
124
calcium ion binding, metalloendopeptidase activity, zinc ion binding
1020
None
TLL2
9606
extracellular region
cell differentiation, collagen fibril organization, extracellular matrix disassembly, multicellular organism development, negative regulation of skeletal muscle tissue growth
10479448
124
26:149
LGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRR