Details of PSQ02098
| ProSeqID |
PSQ02098 |
| Family |
FD00126 |
| Protein Name |
Beta-secretase 2 |
| UniProt ID |
Q9Y5Z0
|
| Taxonomy |
Eukaryota-Metazoa-Chordata-Craniata-Vertebrata-Euteleostomi-Mammalia-Eutheria-Euarchontoglires-Primates-Haplorrhini-Catarrhini-Hominidae-Homo |
| Organisms |
Homo sapiens (Human) |
| Prosequence Length (aa) |
42 |
| Functions |
aspartic-type endopeptidase activity |
| Preproprotein Length (aa) |
518 |
| Alt Name |
Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase |
| Gene Name |
BACE2 |
| NCBI ID |
9606 |
| Cellular Localization |
dense core granule, endoplasmic reticulum, endosome, Golgi apparatus, integral component of membrane, membrane, plasma membrane, trans-Golgi network |
| Processes |
amyloid-beta metabolic process, astrocyte activation, glucose homeostasis, membrane protein ectodomain proteolysis, negative regulation of amyloid precursor protein biosynthetic process, peptide hormone processing, proteolysis |
| PubMed |
10591213,
11083922,
11423558,
16305800,
16816112
|
| Total Prosequence Length (aa) |
42 |
| Prosequence Location |
21:62 |
| Prosequence Sequence |
APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLAL |
| Preproprotein Sequence |
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK |
