PSQ02049
FD00050
Interleukin-36 gamma
Q9NZH8
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
17
cytokine activity, interleukin-1 receptor binding
169
IL-1-related protein 2, Interleukin-1 epsilon, Interleukin-1 family member 9, Interleukin-1 homolog 1
IL36G
9606
cytoplasm, extracellular region, extracellular space
cell-cell signaling, cellular response to lipopolysaccharide, cytokine-mediated signaling pathway, inflammatory response, inflammatory response to antigenic stimulus, innate immune response, positive regulation of gene expression
21965679
17
1:17
MRGTPGDADGGGRAVYQ
PSQ02050
FD00004
Kallikrein-14
Q9P0G3
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
6
serine-type endopeptidase activity
267
Kallikrein-like protein 6
KLK14
9606
extracellular region, extracellular space, secretory granule
cornification, epidermis morphogenesis, fertilization, negative regulation of G protein-coupled receptor signaling pathway, positive regulation of G protein-coupled receptor signaling pathway, proteolysis, seminal clot liquefaction
16800737
6
35:40
QEDENK
PSQ02051
FD00555
A disintegrin and metalloproteinase with thrombospondin motifs 9
Q9P2N4
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
269
metalloendopeptidase activity, metallopeptidase activity, zinc ion binding
1935
None
ADAMTS9
9606
endoplasmic reticulum, extracellular matrix, extracellular region, intracellular membrane-bounded organelle
aorta morphogenesis, endothelial cell-matrix adhesion, extracellular matrix organization, glycoprotein catabolic process, heart valve morphogenesis, multicellular organism development, negative regulation of endothelial cell migration, negative regulation of sprouting angiogenesis, protein transport, proteolysis, ventricular cardiac muscle tissue development, vesicle-mediated transport
12514189
269
19:287
EMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKR
PSQ02075
FD00419
Golgi-associated kinase 1A
Q9UFP1
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
90, 139
None
575
Protein FAM198A
GASK1A
9606
caveola, endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle
None
30188967;30188967
229
30:119, 437:575
VTRFPPQRPSAGPDPGPMEPQGVTGAPATHIRQALSSSRRQRARNMGFWRSRALPRNSILVCAEEQGHRARVDRSRESPGGDLRHPGRVR, RYCCGFEPEPSDPCVEERLREKCQNPAELRLVHILVRSSDPSHLVYIDNAGNLQHPEDKLNFRLLEGIDGFPESAVKVLASGCLQNMLLKSLQMDPVFWESQGGAQGLKQVLQTLEQRGQVLLGHIQKHNLTLFRDEDP
PSQ02076
FD00209
A disintegrin and metalloproteinase with thrombospondin motifs 7
Q9UKP4
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
209
metal ion binding, metalloendopeptidase activity, metallopeptidase activity
1686
COMPase
ADAMTS7
9606
endoplasmic reticulum lumen, extracellular matrix, extracellular region
cellular response to BMP stimulus, cellular response to interleukin-1, cellular response to tumor necrosis factor, extracellular matrix organization, negative regulation of chondrocyte differentiation, proteolysis involved in cellular protein catabolic process
15192113
209
28:236
APGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQR
PSQ02077
FD00507
A disintegrin and metalloproteinase with thrombospondin motifs 5
Q9UNA0
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
245
endopeptidase activity, extracellular matrix binding, heparin binding, integrin binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding
930
A disintegrin and metalloproteinase with thrombospondin motifs 11, ADMP-2, Aggrecanase-2
ADAMTS5
9606
collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular space
defense response to bacterium, extracellular matrix disassembly, extracellular matrix organization, myoblast fusion, negative regulation of cold-induced thermogenesis, proteolysis, tooth eruption
18992360
245
17:261
LAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRR
PSQ02097
FD00448
Heparanase
Q9Y251
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
48
beta-glucuronidase activity, heparanase activity, syndecan binding
543
Endo-glucoronidase, Heparanase-1
HPSE
9606
extracellular matrix, extracellular region, heparanase complex, intracellular membrane-bounded organelle, lysosomal lumen, lysosomal membrane, lysosome, membrane raft, nucleoplasm, nucleus, specific granule lumen
angiogenesis involved in wound healing, cell-matrix adhesion, glycosaminoglycan catabolic process, heparan sulfate proteoglycan catabolic process, neutrophil degranulation, positive regulation of blood coagulation, positive regulation of hair follicle development, positive regulation of osteoblast proliferation, positive regulation of protein kinase B signaling, positive regulation of vascular endothelial growth factor production, proteoglycan metabolic process, regulation of hair follicle development, vascular wound healing
10395326, 10446189, 12713442
48
110:157
STFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQ
PSQ02098
FD00126
Beta-secretase 2
Q9Y5Z0
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
42
aspartic-type endopeptidase activity
518
Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase
BACE2
9606
dense core granule, endoplasmic reticulum, endosome, Golgi apparatus, integral component of membrane, membrane, plasma membrane, trans-Golgi network
amyloid-beta metabolic process, astrocyte activation, glucose homeostasis, membrane protein ectodomain proteolysis, negative regulation of amyloid precursor protein biosynthetic process, peptide hormone processing, proteolysis
10591213, 11083922, 11423558, 16305800, 16816112
42
21:62
APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLAL
PSQ02099
FD00500
Carboxypeptidase Q
Q9Y646
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
24
carboxypeptidase activity, metal ion binding, metallodipeptidase activity, protein homodimerization activity
479
Lysosomal dipeptidase, Plasma glutamate carboxypeptidase
CPQ
9606
cytoplasm, endoplasmic reticulum, extracellular exosome, extracellular space, Golgi apparatus, intracellular membrane-bounded organelle, lysosome
peptide catabolic process, proteolysis, thyroid hormone generation, tissue regeneration
10206990, 12675526
24
21:44
KAICKNGISKRTFEEIKEEIASCG
PSQ02100
FD00185
Tolloid-like protein 2
Q9Y6L7
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
124
calcium ion binding, metalloendopeptidase activity, zinc ion binding
1020
None
TLL2
9606
extracellular region
cell differentiation, collagen fibril organization, extracellular matrix disassembly, multicellular organism development, negative regulation of skeletal muscle tissue growth
10479448
124
26:149
LGERPDATADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRR