activation of cysteine-type endopeptidase activity involved in apoptotic process, adult locomotory behavior, circadian rhythm, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, memory, modulation of chemical synaptic transmission, negative regulation of neuron apoptotic process, negative regulation of type B pancreatic cell apoptotic process, nerve development, nerve growth factor signaling pathway, neuron apoptotic process, neuron development, neuron projection development, neuron projection morphogenesis, peripheral nervous system development, positive regulation of axon extension, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of collateral sprouting, positive regulation of DNA binding, positive regulation of DNA-binding transcription factor activity, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of neuron maturation, positive regulation of neuron projection development, positive regulation of neurotrophin TRK receptor signaling pathway, positive regulation of peptidyl-serine phosphorylation, positive regulation of protein autophosphorylation, positive regulation of protein binding, positive regulation of protein phosphorylation, positive regulation of protein ubiquitination, positive regulation of Ras protein signal transduction, positive regulation of stem cell proliferation, regulation of neuron differentiation, regulation of neurotransmitter secretion, regulation of release of sequestered calcium ion into cytosol, sensory perception of pain, transmembrane receptor protein tyrosine kinase signaling pathway
adrenal gland development, associative learning, cellular response to cocaine, cellular response to dexamethasone stimulus, diterpenoid metabolic process, female pregnancy, glucocorticoid biosynthetic process, hormone-mediated apoptotic signaling pathway, hypothalamus development, inflammatory response, ion homeostasis, learning or memory, locomotory exploration behavior, long-term synaptic potentiation, lung development, negative regulation of cell death, negative regulation of epinephrine secretion, negative regulation of gene expression, negative regulation of glucagon secretion, negative regulation of luteinizing hormone secretion, negative regulation of norepinephrine secretion, negative regulation of systemic arterial blood pressure, positive regulation of behavioral fear response, positive regulation of calcium ion import, positive regulation of cAMP-mediated signaling, positive regulation of cell death, positive regulation of cell population proliferation, positive regulation of corticosterone secretion, positive regulation of corticotropin secretion, positive regulation of cortisol secretion, positive regulation of digestive system process, positive regulation of gene expression, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of protein phosphorylation, regulation of NMDA receptor activity, regulation of serotonin secretion, response to cocaine, response to corticosterone, response to drug, response to estrogen, response to ethanol, response to ether, response to immobilization stress, response to pain, steroid metabolic process, synaptic transmission, dopaminergic
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Suina Suidae Sus
Sus scrofa (Pig)
6
hormone activity, parathyroid hormone receptor binding, peptide hormone receptor binding, protein N-terminus binding, type 1 parathyroid hormone receptor binding
120
Parathyrin
PTH
9823
extracellular space
activation of phospholipase C activity, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell-cell signaling, cellular calcium ion homeostasis, cellular macromolecule biosynthetic process, homeostasis of number of cells within a tissue, magnesium ion homeostasis, negative regulation of apoptotic process in bone marrow cell, negative regulation of gene expression, phosphate ion homeostasis, positive regulation of bone mineralization, positive regulation of cell proliferation in bone marrow, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, positive regulation of inositol phosphate biosynthetic process, positive regulation of osteoclast proliferation, positive regulation of signal transduction, positive regulation of transcription by RNA polymerase II
activation of phospholipase C activity, adenylate cyclase-activating G protein-coupled receptor signaling pathway, bone resorption, cAMP metabolic process, cell-cell signaling, cellular calcium ion homeostasis, cellular macromolecule biosynthetic process, G protein-coupled receptor signaling pathway, homeostasis of number of cells within a tissue, hormone-mediated apoptotic signaling pathway, magnesium ion homeostasis, negative regulation of apoptotic process in bone marrow cell, negative regulation of bone mineralization involved in bone maturation, negative regulation of chondrocyte differentiation, negative regulation of gene expression, negative regulation of inflammatory response to antigenic stimulus, phosphate ion homeostasis, positive regulation of bone mineralization, positive regulation of cell proliferation in bone marrow, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, positive regulation of inositol phosphate biosynthetic process, positive regulation of osteoclast proliferation, positive regulation of signal transduction, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to cadmium ion, response to drug, response to ethanol, response to fibroblast growth factor, response to lead ion, response to parathyroid hormone, response to vitamin D, Rho protein signal transduction, skeletal system development
adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cellular response to glucagon stimulus, feeding behavior, G protein-coupled receptor signaling pathway, glucose homeostasis, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, negative regulation of inflammatory response to antigenic stimulus, positive regulation of calcium ion import, positive regulation of ERK1 and ERK2 cascade, positive regulation of gluconeogenesis, positive regulation of histone H3-K4 methylation, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein binding, positive regulation of protein kinase activity, protein kinase A signaling, regulation of insulin secretion, response to activity
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Lagomorpha Leporidae Oryctolagus
Oryctolagus cuniculus (Rabbit)
43
None
95
Antiadrenocorticotropin peptide III, Corticostatin III, Macrophage antibiotic peptide MCP-1
None
9986
extracellular space
antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to bacterium, defense response to fungus, defense response to virus, killing of cells of other organism
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
112
copper ion binding, cytokine activity, interleukin-1 receptor binding
271
Hematopoietin-1
IL1A
9606
cytosol, extracellular region, extracellular space
apoptotic process, cellular response to heat, cellular response to lipopolysaccharide, cellular sodium ion homeostasis, connective tissue replacement involved in inflammatory response wound healing, cytokine-mediated signaling pathway, ectopic germ cell programmed cell death, extrinsic apoptotic signaling pathway in absence of ligand, fever generation, immune response, inflammatory response, interleukin-1-mediated signaling pathway, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of angiogenesis, positive regulation of cell division, positive regulation of cytokine production, positive regulation of gene expression, positive regulation of immature T cell proliferation in thymus, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of mitotic nuclear division, positive regulation of protein secretion, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of vascular endothelial growth factor production, regulation of nitric-oxide synthase activity, response to copper ion
activation of MAPK activity, apoptotic process, cell-cell signaling, cellular response to drug, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to organic cyclic compound, cellular response to organic substance, cytokine-mediated signaling pathway, embryo implantation, fever generation, hyaluronan biosynthetic process, immune response, inflammatory response, interleukin-1-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, MAPK cascade, monocyte aggregation, negative regulation of adiponectin secretion, negative regulation of cell population proliferation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gap junction assembly, negative regulation of glucose transmembrane transport, negative regulation of insulin receptor signaling pathway, negative regulation of lipid catabolic process, negative regulation of lipid metabolic process, negative regulation of MAP kinase activity, negative regulation of neurogenesis, negative regulation of synaptic transmission, positive regulation of angiogenesis, positive regulation of calcidiol 1-monooxygenase activity, positive regulation of cell adhesion molecule production, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of complement activation, positive regulation of DNA-binding transcription factor activity, positive regulation of epithelial to mesenchymal transition, positive regulation of fever generation, positive regulation of gene expression, positive regulation of glial cell proliferation, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of heterotypic cell-cell adhesion, positive regulation of histone acetylation, positive regulation of histone phosphorylation, positive regulation of immature T cell proliferation in thymus, positive regulation of inflammatory response, positive regulation of interferon-gamma production, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of JNK cascade, positive regulation of lipid catabolic process, positive regulation of membrane protein ectodomain proteolysis, positive regulation of mitotic nuclear division, positive regulation of monocyte chemotactic protein-1 production, positive regulation of myosin light chain kinase activity, positive regulation of neuroinflammatory response, positive regulation of NF-kappaB transcription factor activity, positive regulation of NIK/NF-kappaB signaling, positive regulation of nitric oxide biosynthetic process, positive regulation of p38MAPK cascade, positive regulation of phagocytosis, positive regulation of prostaglandin biosynthetic process, positive regulation of prostaglandin secretion, positive regulation of protein export from nucleus, positive regulation of protein phosphorylation, positive regulation of RNA biosynthetic process, positive regulation of T cell mediated immunity, positive regulation of T cell proliferation, positive regulation of T-helper 1 cell cytokine production, positive regulation of transcription, DNA-templated, positive regulation of vascular endothelial growth factor production, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein kinase B signaling, purinergic nucleotide receptor signaling pathway, regulation of ERK1 and ERK2 cascade, regulation of establishment of endothelial barrier, regulation of I-kappaB kinase/NF-kappaB signaling, regulation of insulin secretion, regulation of neurogenesis, regulation of nitric-oxide synthase activity, response to interleukin-1, response to lipopolysaccharide, sequestering of triglyceride, signal transduction, smooth muscle adaptation, vascular endothelial growth factor production
extracellular matrix structural constituent, identical protein binding, metal ion binding, platelet-derived growth factor binding, protease binding
1453
Alpha-1 type I collagen
Col1a1
10116
collagen trimer, collagen type I trimer, cytoplasm, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, Golgi apparatus, secretory granule
blood vessel development, bone trabecula formation, cartilage development involved in endochondral bone morphogenesis, cellular response to amino acid stimulus, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to fluoride, cellular response to mechanical stimulus, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, cellular response to vitamin E, collagen biosynthetic process, collagen fibril organization, collagen-activated tyrosine kinase receptor signaling pathway, embryonic skeletal system development, endochondral ossification, extracellular matrix organization, face morphogenesis, intramembranous ossification, negative regulation of cell-substrate adhesion, ossification, osteoblast differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of transcription, DNA-templated, protein localization to nucleus, protein transport, response to cAMP, response to corticosteroid, response to drug, response to estradiol, response to fluoride, response to hydrogen peroxide, response to hyperoxia, response to mechanical stimulus, response to nutrient, response to nutrient levels, response to peptide hormone, response to steroid hormone, sensory perception of sound, skeletal system development, skeletal system morphogenesis, skin development, skin morphogenesis, tooth eruption, tooth mineralization, visual perception, wound healing
acute-phase response, cellular protein metabolic process, negative regulation of bone mineralization, negative regulation of endopeptidase activity, negative regulation of insulin receptor signaling pathway, neutrophil degranulation, pinocytosis, platelet degranulation, positive regulation of phagocytosis, post-translational protein modification, regulation of bone mineralization, regulation of inflammatory response, skeletal system development
cellular response to starvation, maintenance of mitochondrion location, negative regulation of apoptotic process, positive regulation of circadian sleep/wake cycle, non-REM sleep, response to mercury ion, response to nutrient, response to organic substance, response to platinum ion, vasodilation
bone development, bone mineralization, cell adhesion, cell aging, cellular response to growth factor stimulus, cellular response to vitamin D, endoplasmic reticulum to Golgi vesicle-mediated transport, odontogenesis, osteoblast development, osteoblast differentiation, regulation of bone mineralization, regulation of bone resorption, regulation of cellular response to insulin stimulus, regulation of osteoclast differentiation, response to activity, response to drug, response to estrogen, response to ethanol, response to glucocorticoid, response to gravity, response to hydroxyisoflavone, response to mechanical stimulus, response to testosterone, response to vitamin D, response to vitamin K, response to zinc ion, skeletal system development
calcium ion binding, hydroxyapatite binding, structural constituent of bone
100
Bone Gla protein, Gamma-carboxyglutamic acid-containing protein
BGLAP
9913
cytoplasm, extracellular region
biomineral tissue development, bone development, osteoblast differentiation, regulation of bone mineralization, regulation of cellular response to insulin stimulus, response to vitamin K
calcium ion binding, hydroxyapatite binding, structural constituent of bone
97
Bone Gla protein, Gamma-carboxyglutamic acid-containing protein
BGLAP
9031
extracellular region
biomineral tissue development, bone development, osteoblast differentiation, regulation of bone mineralization, regulation of cellular response to insulin stimulus, response to vitamin K
cellular response to amino acid stimulus, cellular response to cell-matrix adhesion, cellular response to interleukin-1, cellular response to UV-A, collagen catabolic process, extracellular matrix organization, female pregnancy, negative regulation of hydrogen peroxide metabolic process, negative regulation of protein kinase B signaling, positive regulation of cell migration, positive regulation of oxidative stress-induced cell death, positive regulation of protein-containing complex assembly, protein catabolic process, proteolysis, regulation of cell migration, response to amino acid, response to cytokine, response to estradiol, response to hypoxia, response to interleukin-1, response to lipopolysaccharide, response to mechanical stimulus, response to tumor necrosis factor, wound healing