PSQ00601
FD00290
Extracellular superoxide dismutase
O09164
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus
Mus musculus (Mouse)
9
copper ion binding, superoxide dismutase activity
251
None
Sod3
10090
collagen-containing extracellular matrix, cytoplasm, extracellular space, Golgi lumen, nucleus
blood vessel diameter maintenance, removal of superoxide radicals, response to copper ion, response to hypoxia
9376114
9
16:24
SVTMSNPGE
PSQ00602
FD00167
Prosaposin
O13035
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae Phasianinae Gallus
Gallus gallus (Chicken)
50
None
518
Proactivator polypeptide
PSAP
9031
extracellular space, lysosome
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, regulation of lipid metabolic process, sphingolipid metabolic process
9461526
50
144:193
KHLAAMKLQKQLQSNKIPELDFSELTSPFMANVPLLLYPQDKPKQKSKAT
PSQ00603
FD00087
Tripeptidyl-peptidase 1
O14773
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
176
endopeptidase activity, lysophosphatidic acid binding, metal ion binding, peptidase activity, peptide binding, serine-type endopeptidase activity, serine-type peptidase activity, sulfatide binding, tripeptidyl-peptidase activity
563
Cell growth-inhibiting gene 1 protein, Lysosomal pepstatin-insensitive protease, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I
TPP1
9606
extracellular exosome, Golgi apparatus, lysosomal lumen, lysosome, melanosome, membrane raft, recycling endosome
bone resorption, central nervous system development, epithelial cell differentiation, IRE1-mediated unfolded protein response, lipid metabolic process, lysosomal protein catabolic process, lysosome organization, nervous system development, neuromuscular process controlling balance, peptide catabolic process, protein catabolic process, protein localization to chromosome, telomeric region, proteolysis
11054422, 25944712
176
20:195
SYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVG
PSQ00604
FD00031
Defensin-2
O16137
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Muscoidea Muscidae Stomoxys
Stomoxys calcitrans (Stable fly) (Conops calcitrans)
34
None
97
None
SMD2
35570
extracellular region
defense response to bacterium, innate immune response
9326639
34
24:57
APSAGNEVDHHPDYVDGVEALRQLEPELHGRYKR
PSQ00605
FND00350
Kappa-stichotoxin-Hmg1a
O16846
Eukaryota Metazoa Cnidaria Anthozoa Hexacorallia Actiniaria Stichodactylidae Heteractis
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
17
toxin activity
74
Potassium channel toxin HmK
None
38281
extracellular region, nematocyst
None
9298966
17
23:39
RMELQDVEDMENGFQKR
PSQ00606
FND00053
Ceratotoxin-A
O17512
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Tephritoidea Tephritidae Ceratitis Ceratitis
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
12
None
71
None
CTXA2
7213
extracellular region
defense response to bacterium, hemolysis in other organism, innate immune response
8353519
12
24:35
EPAAEDSIVVKR
PSQ00607
FD00090
Clavanin-C
O18493
Eukaryota Metazoa Chordata Tunicata Ascidiacea Stolidobranchia Styelidae Styela
Styela clava (Sea squirt)
10
None
80
None
None
7725
extracellular region
defense response to bacterium
9001389
10
20:29
LEERKSEEEK
PSQ00608
FD00107
Vacuolar-processing enzyme
O24325
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Papilionoideae 50 kb inversion clade NPAAA clade indigoferoid/millettioid clade Phaseoleae Phaseolus
Phaseolus vulgaris (Kidney bean) (French bean)
20
cysteine-type endopeptidase activity
484
Legumain-like proteinase
None
3885
None
proteolysis involved in cellular protein catabolic process
9874222
20
25:44
GRDLVGDFLRLPSDSGNGDN
PSQ00609
FD00376
Sporulation killing factor
O31422
Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus
Bacillus subtilis (strain 168)
29
None
60
Sporulation-killing factor SkfA
skfA
224308
extracellular region
cytolysis, defense response to bacterium
20805502
29
1:29
MKRNQKEWESVSKKGLMKPGGTSIVKAAG
PSQ00610
FD00289
Sporulation delaying protein C
O34344
Bacteria Firmicutes Bacilli Bacillales Bacillaceae Bacillus
Bacillus subtilis (strain 168)
108, 21
toxin activity
203
Cannibalism toxin SDP , Killing factor SdpC, Toxic peptide SdpC
sdpC
224308
extracellular region
cell killing, cytolysis, defense response to bacterium, pathogenesis
20805502;20805502
129
33:140, 183:203
KENHTFSGEDYFRGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSIDSKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPS, SASNNSDLEAAAAKTLKLIHQ
PSQ00611
FD00251
Pro-neuregulin-2
O35569
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus
Rattus norvegicus (Rat)
127
epidermal growth factor receptor binding, epidermal growth factor-activated receptor activity, ErbB-3 class receptor binding, growth factor activity, signaling receptor binding
868
None
Nrg2
10116
extracellular space, GABA-ergic synapse, glutamatergic synapse, integral component of membrane, plasma membrane
animal organ development, epidermal growth factor receptor signaling pathway, intracellular signal transduction, nervous system development, regulation of synapse assembly, regulation of synapse maturation
9348101
127
1:127
MRQVCCSALPPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSENSGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGSSMLLFGVSLA
PSQ00612
FD00004
Thrombin-like enzyme CPI-enzyme 2
O42207
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Viperidae Crotalinae Gloydius
Gloydius ussuriensis (Ussuri mamushi) (Gloydius blomhoffii ussuriensis)
6
serine-type endopeptidase activity, toxin activity
258
Capillary permeability-increasing enzyme 2
None
35671
extracellular region
None
8303716
6
19:24
QKSSEL
PSQ00613
FD00106
Endopolygalacturonase E
O42809
Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Aspergillus Aspergillus subgen Circumdati
Aspergillus niger
20
polygalacturonase activity
378
Pectinase 4, Pectinase E, Polygalacturonase E, Polygalacturonase IV
pgaE
5061
extracellular region
carbohydrate metabolic process, cell wall organization
9492270
20
20:39
SPVADPLVTPAPKLEDLEKR
PSQ00614
FD00189
Serine protease HTRA2
O43464
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
102
identical protein binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity, unfolded protein binding
458
High temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI
HTRA2
9606
CD40 receptor complex, chromatin, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleus, serine-type endopeptidase complex
adult walking behavior, aging, cellular protein catabolic process, cellular response to growth factor stimulus, cellular response to heat, cellular response to interferon-beta, cellular response to oxidative stress, cellular response to retinoic acid, ceramide metabolic process, execution phase of apoptosis, forebrain development, intrinsic apoptotic signaling pathway in response to DNA damage, mitochondrion organization, negative regulation of cell cycle, negative regulation of mitophagy in response to mitochondrial depolarization, negative regulation of neuron death, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, neuron development, pentacyclic triterpenoid metabolic process, positive regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of mitochondrion organization, positive regulation of protein targeting to mitochondrion, programmed cell death, protein autoprocessing, proteolysis, regulation of autophagy of mitochondrion, regulation of multicellular organism growth, response to herbicide
11583623
102
32:133
TPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLA
PSQ00615
FD00244
Peptidase inhibitor 15
O43692
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
41
peptidase inhibitor activity
258
25 kDa trypsin inhibitor, Cysteine-rich secretory protein 8, SugarCrisp
PI15
9606
extracellular exosome, extracellular space
multicellular organism development
8882727
41
20:60
STVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKR
PSQ00616
FD00129
Vascular endothelial growth factor D
O43915
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
67
chemoattractant activity, growth factor activity, identical protein binding, platelet-derived growth factor receptor binding, vascular endothelial growth factor receptor 3 binding, vascular endothelial growth factor receptor binding
360
c-Fos-induced growth factor
VEGFD
9606
extracellular region, extracellular space, membrane, platelet alpha granule lumen
cell population proliferation, dopaminergic neuron differentiation, induction of positive chemotaxis, platelet degranulation, positive regulation of angiogenesis, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of endothelial cell proliferation, positive regulation of mast cell chemotaxis, positive regulation of protein phosphorylation, response to bacterium, response to hypoxia, sprouting angiogenesis, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway
10542248
67
22:88
SSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTR
PSQ00617
FND00316
Potassium channel toxin alpha-KTx 10
O46028
Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Centruroides
Centruroides noxius (Mexican scorpion)
6
toxin activity
62
Cobatoxin-1 , gtIX
None
6878
extracellular region
None
9688256
6
23:28
NWNTEA
PSQ00618
FD00464
L-galactono-1,4-lactone dehydrogenase, mitochondrial
O47881
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Brassiceae Brassica
Brassica oleracea (Wild cabbage)
66
D-arabinono-1,4-lactone oxidase activity, FAD binding, galactonolactone dehydrogenase activity, L-gulono-1,4-lactone dehydrogenase activity
600
None
None
3712
integral component of membrane, mitochondrial membrane, plastid
L-ascorbic acid biosynthetic process
9374475
66
26:91
CTSGQTLTPAPPPPPPPPPPISSSASEKEFRKYAGYAALALFSGAATYFSFPFPENAKHKKAQIFR
PSQ00619
FD00036
Lantibiotic mutacin-2
O54329
Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus
Streptococcus mutans
26
signaling receptor binding
60
Lantibiotic mutacin H-29B, Mutacin II
mutA
1309
extracellular region
amino acid transport, cytolysis, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, regulation of membrane potential
10821848, 16626493, 8021218, 9647795
26
1:26
MNKLNSNAVVSLNEVSDSELDTILGG
PSQ00620
FD00186
Zona pellucida sperm-binding protein 1
O54766
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus
Rattus norvegicus (Rat)
73
structural constituent of egg coat
617
Zona pellucida glycoprotein 1
Zp1
10116
collagen-containing extracellular matrix, egg coat, extracellular region, integral component of membrane, plasma membrane
single fertilization
16342937
73
545:617
RRSSGHHNSTIRALDIVSSPGAVGFEDAPKLEPSGSTRNSGSRPLLWVLQLLALTLVLGDGVLVGLSWAWAWA
PSQ00621
FD00124
Sortilin
O54861
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Rattus
Rattus norvegicus (Rat)
42
enzyme binding, G protein-coupled neurotensin receptor activity, nerve growth factor binding, nerve growth factor receptor activity, neurotensin receptor activity, non-G protein-coupled, retromer complex binding
825
Glycoprotein 110, Neurotensin receptor 3
Sort1
10116
cell surface, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, dendrite, early endosome, endoplasmic reticulum membrane, endosome membrane, Golgi apparatus, Golgi cisterna membrane, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome, neuronal cell body, nuclear membrane, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network transport vesicle
endocytosis, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, extrinsic apoptotic signaling pathway via death domain receptors, G protein-coupled receptor signaling pathway, glucose import, Golgi to endosome transport, Golgi to lysosome transport, intracellular protein transport, multicellular organism development, myotube differentiation, negative regulation of fat cell differentiation, negative regulation of lipoprotein lipase activity, neuropeptide signaling pathway, neurotrophin TRK receptor signaling pathway, ossification, plasma membrane to endosome transport, positive regulation of epithelial cell apoptotic process, post-Golgi vesicle-mediated transport, protein targeting to lysosome, regulation of gene expression, response to insulin, vesicle organization
26479776
42
32:73
QDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRW
PSQ00622
FD00077
Acetylxylan esterase 2
O59893
Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Trichocomaceae Talaromyces Talaromyces sect Talaromyces
Talaromyces purpureogenus (Soft rot fungus) (Penicillium purpureogenum)
10
acetylxylan esterase activity
240
AXE II
axe-2
1266744
extracellular region
cellulose catabolic process, xylan catabolic process
8756392, 9506837
10
18:27
IPLEGVMEKR
PSQ00623
FD00085
Aspartic protease
O60020
Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Cystofilobasidiales Mrakiaceae Phaffia
Phaffia rhodozyma (Yeast) (Xanthophyllomyces dendrorhous)
60
aspartic-type endopeptidase activity
405
None
pr1
264483
extracellular region
proteolysis
10091328
60
22:81
APVDATATSTSGIIAVPISKSAAQLAREADPVVSLDWLKKTKAQAQYKHKQANARLHSKR
PSQ00624
FD00396
Cubilin
O60494
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
12
calcium ion binding, cargo receptor activity, cobalamin binding, protein homodimerization activity, signaling receptor activity
3623
460 kDa receptor, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor
CUBN
9606
apical plasma membrane, brush border membrane, clathrin-coated pit, cytosol, endocytic vesicle, endoplasmic reticulum, endosome membrane, extracellular exosome, extrinsic component of external side of plasma membrane, Golgi apparatus, lysosomal lumen, lysosomal membrane, membrane, plasma membrane, receptor complex
cholesterol metabolic process, cobalamin metabolic process, cobalamin transport, high-density lipoprotein particle clearance, lipoprotein transport, receptor-mediated endocytosis, response to bacterium, tissue homeostasis, vitamin D metabolic process
9572993
12
24:35
EAGELELQRQKR
PSQ00625
FND00160
Kinetoplast-associated protein 1
O61016
Eukaryota Discoba Euglenozoa Kinetoplastea Metakinetoplastina Trypanosomatida Trypanosomatidae Leishmaniinae Crithidia
Crithidia fasciculata
9
DNA binding
151
Histone H1-like protein p21
KAP4
5656
kinetoplast
None
8446592
9
1:9
MLRVSVRSL
PSQ00626
FD00371
Subtilisin-like protease 1
O61142
Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida Plasmodiidae Plasmodium Plasmodium (Laverania)
Plasmodium falciparum
194
metal ion binding, serine-type endopeptidase activity
690
PfSUB-1
SUB1
5833
extracellular region
None
12764150, 10617661
194
26:219
KEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSAD
PSQ00627
FD00159
Plasmatocyte-spreading peptide
O61704
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Plusiinae Chrysodeixis
Chrysodeixis includens (Soybean looper) (Pseudoplusia includens)
96
cytokine activity
141
None
PSP1
689277
extracellular space
None
9287360
96
23:118
NLRDLFNNVRGSISSSANKIRQDVKTLFHPSDKSGNKESSNIVFVEDKDEGAVGPARDNKPVAVTPAPVVSTTTQASAPTVATNGTATGGKDDKGR
PSQ00628
FD00056
Subtilisin-like protease SBT1
O65351
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis
Arabidopsis thaliana (Mouse-ear cress)
82
serine-type endopeptidase activity
757
Cucumisin-like serine protease, Subtilase subfamily 1 member 7 , Subtilisin-like serine protease 1
SBT1
3702
apoplast, cell wall, extracellular region, secretory vesicle
mucilage extrusion from seed coat, mucilage metabolic process involved in seed coat development, seed coat development
12413398, 9188482
82
25:106
SSSDQGTYIVHMAKSQMPSSFDLHSNWYDSSLRSISDSAELLYTYENAIHGFSTRLTQEEADSLMTQPGVISVLPEHRYELH
PSQ00629
FD00567
Lantibiotic mutacin-1140
O68586
Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus
Streptococcus mutans
41
signaling receptor binding
63
Mutacin III
lanA
1309
extracellular region
cytolysis, defense response to bacterium
11082191
41
1:41
MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTR
PSQ00630
FD00228
Trehalose phosphorylase
O75003
Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Polyporales Grifolaceae Grifola
Grifola frondosa (Maitake) (Polyporus frondosus)
25
alpha,alpha-trehalose phosphorylase (configuration-retaining) activity
732
Trehalose synthase
None
5627
None
glucose 6-phosphate metabolic process, glucose metabolic process, trehalose metabolic process
9763690
25
1:25
MAPPHQFQSKPSDVIRRRLSSAVSS
PSQ00631
FD00531
Attractin
O75882
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo
Homo sapiens (Human)
55
carbohydrate binding, signaling receptor activity
1429
DPPT-L, Mahogany homolog
ATRN
9606
basement membrane, cytoplasm, extracellular exosome, extracellular space, integral component of plasma membrane, plasma membrane
animal organ morphogenesis, cell migration, cerebellum development, inflammatory response, myelination, pigmentation, regulation of multicellular organism growth, response to oxidative stress, substrate adhesion-dependent cell spreading, tissue development
17261078
55
29:83
PHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEA
PSQ00632
FD00146
Delta-ctenitoxin-Pn2c
O76199
Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Ctenidae Phoneutria
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
17
toxin activity
82
Neurotoxin Pn2-5A , Neurotoxin Tx2-5
None
6918
extracellular region
None
1397265, 16278100, 1801316, 19231838
17
18:34
ESIEESRDDFAVEELGR
PSQ00633
FD00178
Kappa-ctenitoxin-Pn1a
O76200
Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Ctenidae Phoneutria
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
16, 6
ion channel inhibitor activity, toxin activity
83
Neurotoxin Tx3-1 , PNTx3-1, PhKv
None
6918
extracellular region
pathogenesis
8446961;8446961
22
22:37, 78:83
EPNSSPNNPLIVEEDR, LFGFGK
PSQ00634
FD00178
Omega-ctenitoxin-Pn1a
O76201
Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Ctenidae Phoneutria
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
16
ion channel inhibitor activity, toxin activity
82
Neurotoxin Tx3-2, PNTx3-2
None
6918
extracellular region
pathogenesis
8446961
16
22:37
EPNSSPNNPLIEEEAR
PSQ00635
FD00085
Cathepsin D
O76856
Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia Dictyosteliales Dictyosteliaceae Dictyostelium
Dictyostelium discoideum (Slime mold)
30
aspartic-type endopeptidase activity
383
Ddp44
ctsD
44689
early endosome, early phagosome, extracellular region, lysosome, phagocytic vesicle
programmed cell death
10523518
30
19:48
LTVPLNFHQASRESRRRVPQKWSNRLSALN
PSQ00636
FND00152
Bomanin Short 2
O77150
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
7
None
45
Bomanin-2 , Immune-induced peptide 2
BomS2
7227
extracellular region
defense response, innate immune response, response to bacterium
12171930
7
21:27
VPLSPDP
PSQ00637
FND00223
Precursor of CEP3
O80460
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis
Arabidopsis thaliana (Mouse-ear cress)
39
hormone activity
82
None
CEP3
3702
apoplast, extracellular region
cellular response to nitrogen starvation, nitrate import, regulation of lateral root development, regulation of leaf morphogenesis, regulation of root development, regulation of shoot system development, response to auxin, response to carbon dioxide, response to light intensity, response to nitrate starvation, response to nitrogen compound, response to osmotic stress, response to potassium ion, response to salt stress, response to sucrose, response to temperature stimulus, root development
25324386
39
25:63
RKLTKFTVTTSEEIRAGGSVLSSSPPTEPLESPPSHGVD
PSQ00638
FD00086
Arabinogalactan protein 16
O82337
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis
Arabidopsis thaliana (Mouse-ear cress)
36
None
73
Arabinogalactan peptide 16
AGP16
3702
anchored component of membrane, plasma membrane
None
11006345, 15322080
36
38:73
DGTSIDQGIAYLLMVVALVLTYLIHPLDASSSYSFF
PSQ00639
FD00056
Subtilisin-like protease SBT3
O82777
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Solanales Solanaceae Solanoideae Solaneae Solanum Solanum subgen Lycopersicon
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
90
identical protein binding, protein homodimerization activity, serine-type endopeptidase activity, serine-type peptidase activity
761
LeSBT3 , SlSBT3 , Subtilase 3
sbt3
4081
extracellular space
defense response, peptide catabolic process, plant-type cell wall modification, positive regulation of defense response to insect, positive regulation of gene expression, proteolysis, regulation of cell wall pectin metabolic process, response to wounding, self proteolysis
19332543
90
23:112
QRSTYIVHLDKSLMPNVFTDHHHWHSSTIDSIKASVPSSVDRFHSAPKLVYSYDNVLHGFSAVLSKDELAALKKLPGFISAYKDRTVEPH
PSQ00640
FD00144
Serine-aspartate repeat-containing protein D
O86488
Bacteria Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus
Staphylococcus aureus (strain Newman)
34
None
1320
None
sdrD
426430
cell wall, extracellular region
cell adhesion
11830639
34
1282:1315
GNENSGSNNATLFGGLFAALGSLLLFGRRKKQNK
PSQ00641
FD00256
Serine-aspartate repeat-containing protein E
O86489
Bacteria Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus
Staphylococcus aureus (strain Newman)
34
None
1166
None
sdrE
426430
cell wall, extracellular region
cell adhesion, pathogenesis
11830639
34
1133:1166
GSENNGSNNATLFGGLFAALGSLLLFGRRKKQNK
PSQ00642
FD00038
Lantibiotic lacticin 3147 A1
O87236
Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Lactococcus
Lactococcus lactis subsp
29
signaling receptor binding
60
None
ltnA1
1360
extracellular region
cytolysis, defense response to Gram-positive bacterium
10608807, 15023056
29
1:29
MNKNEIETQPVTWLEEVSDQNFDEDVFGA
PSQ00643
FND00296
Lantibiotic lacticin 3147 A2
O87237
Bacteria Firmicutes Bacilli Lactobacillales Streptococcaceae Lactococcus
Lactococcus lactis subsp
36
signaling receptor binding
65
None
ltnA2
1360
extracellular region
cytolysis, defense response to Gram-positive bacterium
15023056
36
1:36
MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGG
PSQ00644
FD00278
Lanthionine-containing peptide SapB precursor RamS
O88038
Bacteria Actinobacteria Streptomycetales Streptomycetaceae Streptomyces Streptomyces albidoflavus group
Streptomyces coelicolor (strain ATCC BAA-471
21
None
42
ProSapB
ramS
100226
extracellular region, plasma membrane, spore wall
None
15277670, 2032288
21
1:21
MNLFDLQSMETPKEEAMGDVE
PSQ00645
FD00208
Caspase-8
O89110
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus
Mus musculus (Mouse)
218, 11
cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in execution phase of apoptosis, death effector domain binding, death receptor binding, endopeptidase activity, identical protein binding, peptidase activity, protein-containing complex binding, scaffold protein binding, tumor necrosis factor receptor binding, ubiquitin protein ligase binding
480
None
Casp8
10090
CD95 death-inducing signaling complex, cell body, cytoplasm, cytosol, death-inducing signaling complex, membrane raft, mitochondrion, neuron projection, Noc1p-Noc2p complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ripoptosome
activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, apoptotic process, apoptotic signaling pathway, cardiac muscle tissue development, execution phase of apoptosis, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, heart development, hepatocyte apoptotic process, macrophage differentiation, negative regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of necroptotic process, neural tube formation, positive regulation of apoptotic process, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-1 beta production, positive regulation of macrophage differentiation, positive regulation of neuron death, positive regulation of proteolysis, protein processing, proteolysis, proteolysis involved in cellular protein catabolic process, pyroptosis, regulation of apoptotic signaling pathway, regulation of cytokine production, regulation of innate immune response, regulation of thymocyte apoptotic process, response to ethanol, response to tumor necrosis factor, self proteolysis, TRAIL-activated apoptotic signaling pathway
31511692;31511692
229
1:218, 377:387
MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQD, FEQQNHTLEVD
PSQ00646
FD00193
Cathepsin D
O93428
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Perciformes Notothenioidei Channichthyidae Chionodraco
Chionodraco hamatus (Antarctic teleost icefish) (Chaenichthys rhinoceratus, hamatus)
43
aspartic-type endopeptidase activity
396
None
ctsd
36188
lysosome
proteolysis
10209280
43
19:61
LVRIPLKKFRSIRRQLTDSGKRAEELLADHHSLKYNLSFPASN
PSQ00647
FND00016
Plasticin-DA1
O93454
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Hyloidea Hylidae Phyllomedusinae Agalychnis
Agalychnis dacnicolor (Giant mexican leaf frog) (Pachymedusa dacnicolor)
20
None
71
Dermaseptin PD-3-6
None
75988
extracellular region, membrane, other organism cell membrane
defense response, hemolysis in other organism
15222751
20
23:42
EAEKREEENEEKQEDDDESE
PSQ00648
FD00061
Cholecystokinin
O93464
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Cyprinidae Cyprininae Carassius
Carassius auratus (Goldfish)
84, 9
hormone activity
123
CCK8
cck
7957
extracellular region
feeding behavior, growth hormone secretion, peptide hormone secretion
9493851;9493851
93
20:103, 115:123
LSLPAVSEDGGQSDLGIVMEHTRHTRAAPSSGQLSLLSKAEDDEEPRSSLTELLARIISTKGTYRRSPSPKSKSMGNNHRIKDR, SAEEYEYSS
PSQ00649
FD00327
Phosphatidylglycerol
O94183
Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Aspergillus Aspergillus subgen Circumdati
Aspergillus oryzae (strain ATCC 42149
16
None
180
None
pltp
510516
cytoplasmic vesicle, Golgi apparatus
intracellular sterol transport
7742351
16
22:37
RSLDFFKSSQSPIQAQ
PSQ00650
FD00027
Versatile peroxidase VPL2
O94753
Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Pleurotaceae Pleurotus
Pleurotus eryngii (Boletus of the steppes)
8
23:30
361
Versatile liquid phase peroxidase 2
vpl2
5323
extracellular region
hydrogen peroxide catabolic process, lignin catabolic process, response to oxidative stress
9987124
8
23:30
AVPLVQKR