PSQ00223
FND00012
Drosulfakinins
B2ZB95
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila erecta (Fruit fly)
42, 26
neuropeptide hormone activity, neuropeptide receptor binding
141
None
Dsk
7220
extracellular region
adult feeding behavior, adult locomotory behavior, larval locomotory behavior, multicellular organismal response to stress, neuromuscular junction development, neuropeptide signaling pathway, positive regulation of cytosolic calcium ion concentration, regulation of smooth muscle contraction, smooth muscle contraction
17632121;17632121
68
32:73, 86:111
QTTSLQISKEDRRLQELESKMGAESEQPNANLVGPSISRFGD, VPLISRPMIPIELDLLMDNDDERTKA
PSQ00224
FND00012
Drosulfakinins
B2ZB96
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila mauritiana (Fruit fly)
40, 26
hormone activity
141
None
Dsk
7226
extracellular region
neuropeptide signaling pathway, smooth muscle contraction
17632121;17632121
66
34:73, 86:111
TSLQNAKDDRRLQELESKIGAESDQPNANLVGPSFSRFGD, VPLISRPMIPIELDLLMDNDDERTKA
PSQ00225
FND00012
Drosulfakinins
B2ZB98
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila sechellia (Fruit fly)
40, 26
neuropeptide hormone activity, neuropeptide receptor binding
141
None
Dsk
7238
extracellular region
adult feeding behavior, adult locomotory behavior, larval locomotory behavior, multicellular organismal response to stress, neuromuscular junction development, neuropeptide signaling pathway, positive regulation of cytosolic calcium ion concentration, regulation of smooth muscle contraction, smooth muscle contraction
17632121;17632121
66
34:73, 86:111
TSLQNAKDDRRLQELESKIGAESDQPNANLVGPSFSRFGD, VPLISRPMIPIELDLLMDNDDERTKA
PSQ00226
FND00012
Drosulfakinins
B2ZB99
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila simulans (Fruit fly)
42, 26
neuropeptide hormone activity, neuropeptide receptor binding
141
None
Dsk
7240
extracellular region
adult feeding behavior, adult locomotory behavior, larval locomotory behavior, multicellular organismal response to stress, neuromuscular junction development, neuropeptide signaling pathway, positive regulation of cytosolic calcium ion concentration, regulation of smooth muscle contraction, smooth muscle contraction
17632121;17632121
68
32:73, 86:111
QTTSLQNAKDDRRLQELESKIGAESDQTNANLVGPSFSRFGD, VPLISRPMIPIELDLLMDNDDERTKA
PSQ00227
FND00012
Drosulfakinins
B2ZBA0
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila teissieri (Fruit fly)
40, 23
hormone activity
138
None
Dsk
7243
extracellular region
neuropeptide signaling pathway, smooth muscle contraction
17632121;17632121
63
34:73, 86:108
TSLQISKGDRRLQDLESNMGAESDQPNANLVGTSLSRFGD, VPRPIIPIELDLLMDNDDENTKA
PSQ00228
FND00012
Drosulfakinins
B2ZBA1
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila yakuba (Fruit fly)
43, 23
hormone activity
137
None
Dsk
7245
extracellular region
neuropeptide signaling pathway, smooth muscle contraction
17632121;17632121
66
32:74, 85:107
QTNLQTSKGDRRLQDLESNMGAESDQPNANLVRPSLSRFGDKR, VPRPMIPIELDLLMDNDDENTKA
PSQ00268
FD00141
Neurotrophin 1
B7TB45
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
469
growth factor activity, receptor ligand activity, Toll binding
886
Neurotrophic factor 1 , Protein spaetzle 2 , Protein spatzle 2
NT1
7227
extracellular region, extracellular space
axon guidance, central nervous system formation, innate immune response, motor neuron axon guidance, nervous system development, regulation of cell death, regulation of neuronal synaptic plasticity in response to neurotrophin, regulation of Toll signaling pathway, Toll signaling pathway
24124519
469
30:498
DDELMDFDFADSNDAAMEDWQLDDLEEAKKAEQAEKKLESNMLDFSVDLDEPEPEKQLPPFDWRERVLRNALAKALADEGLRQKFAEVLPILRMLSSQQRLALSALISAQMNAKKGHELKFEQVRMMFGNEKKLLLPIVFDIANLIKSSTRKYINLGSDLASSALYHTPINRREDDLTPEESQQDDQLGTIAVEVEPKKVSTEEVQLESLEDFFDEMGSEVLDPQMINEALTGDLHDNKTKTFKPENHGQRVRRSANEFVHKLTRSVPASVTEQQLLGGIAGRTIKLNTTAFQQPSSQEEEKMASSNGGQSYSEVEDLAFAGLNGTEIPLSADERLDLQRNSAEETEEPLPSPEELIAGPRYRLGKRPLPGQKSGSPIKRKRVTSSLRGRPKTAASSHKPVVTPPNKKCERFTSNMCIRTDDYPLEQIMGSIRRHKNAMSALLAEFYDKPNNNLEFSDDFDDFSLSKKR
PSQ00596
FD00131
Caspase-1
O02002
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
13
BIR domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in execution phase of apoptosis
323
None
Dcp-1
7227
cytoplasm, cytosol, messenger ribonucleoprotein complex, mitochondrion, neuronal cell body, neuronal ribonucleoprotein granule
apoptotic process, cellular response to starvation, cytoplasmic transport, nurse cell to oocyte, execution phase of apoptosis, multicellular organism development, negative regulation of apoptotic process, negative regulation of neuromuscular synaptic transmission, neuron remodeling, nurse cell apoptotic process, oogenesis, ovarian nurse cell to oocyte transport, positive regulation of autophagy, positive regulation of macroautophagy, programmed cell death, programmed cell death involved in cell development
8999799
13
203:215
GGITLEKGVTETD
PSQ00636
FND00152
Bomanin Short 2
O77150
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
7
None
45
Bomanin-2 , Immune-induced peptide 2
BomS2
7227
extracellular region
defense response, innate immune response, response to bacterium
12171930
7
21:27
VPLSPDP
PSQ00807
FD00440
Protein decapentaplegic
P07713
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
433
BMP receptor binding, collagen binding, cytokine activity, growth factor activity, heparin binding, morphogen activity, protein heterodimerization activity, protein homodimerization activity, receptor ligand activity
588
None
dpp
7227
cell leading edge, dense core granule lumen, extracellular space
amnioserosa formation, anterior Malpighian tubule development, BMP signaling pathway, cardioblast differentiation, cell chemotaxis involved in Malpighian tubule morphogenesis, chorion-containing eggshell formation, compound eye morphogenesis, dorsal appendage formation, dorsal closure, dorsal/ventral axis specification, dorsal/ventral pattern formation, ectodermal cell fate specification, embryonic hindgut morphogenesis, epithelial cell migration, open tracheal system, eye-antennal disc development, eye-antennal disc morphogenesis, female germ-line stem cell population maintenance, fusion cell fate specification, genital disc anterior/posterior pattern formation, genital disc development, genital disc sexually dimorphic development, germ cell development, germ cell migration, germ-line stem cell division, germ-line stem cell population maintenance, head morphogenesis, heart development, hemocyte development, hindgut morphogenesis, imaginal disc development, imaginal disc-derived wing morphogenesis, imaginal disc-derived wing vein morphogenesis, imaginal disc-derived wing vein specification, labial disc development, larval lymph gland hemocyte differentiation, lymph gland development, male germ-line stem cell population maintenance, Malpighian tubule morphogenesis, maternal specification of dorsal/ventral axis, oocyte, soma encoded, mesoderm development, negative regulation of gene expression, negative regulation of salivary gland boundary specification, ovarian follicle cell development, pericardial nephrocyte differentiation, positive regulation of gene expression, positive regulation of imaginal disc growth, positive regulation of muscle organ development, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of SMAD protein signal transduction, progression of morphogenetic furrow involved in compound eye morphogenesis, R8 cell fate specification, regulation of cell differentiation, regulation of cell shape, regulation of imaginal disc growth, regulation of stem cell differentiation, regulation of tube diameter, open tracheal system, SMAD protein signal transduction, spectrosome organization, wing and notum subfield formation, wing disc pattern formation, zygotic specification of dorsal/ventral axis
1692958
433
24:456
EDISQRFIAAIAPVAAHIPLASASGSGSGRSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIR
PSQ01286
FD00538
Drosomycin
P41964
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
6
None
70
Cysteine-rich peptide
Drs
7227
extracellular space
antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to fungus, defense response to Gram-negative bacterium, defense response to protozoan, killing of cells of other organism, response to bacterium, response to wounding
7806546
6
21:26
ANEADA
PSQ01485
FND00157
Daisho1
P82705
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
6
None
42
Immune-induced peptide 4
Dso1
7227
extracellular region, extracellular space
cell morphogenesis, defense response, humoral immune response, innate immune response, positive regulation of antifungal innate immune response, response to bacterium, Toll signaling pathway
12171930, 9736738
6
21:26
EPVPQP
PSQ01486
FD00556
Bomanin Short 1
P82706
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
7
None
45
Bomanin-1 , Immune-induced peptide 1
BomS1
7227
extracellular region
defense response, innate immune response, response to bacterium
9736738
7
21:27
VPLSPDP
PSQ01751
FND00156
Neuropeptide CCHamide-1
Q4V4I9
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
144
neuropeptide hormone activity
182
None
CCHa1
7227
extracellular space
neuropeptide signaling pathway
21214272, 23293632
144
39:182
SGGKAVIDAKQHPLPNSYGLDSVVEQLYNNNNNNQNNQDDDNNDDDSNRNTNANSANNIPLAAPAIISRRESEDRRIGGLKWAQLMRQHRYQLRQLQDQQQQGRGRGGQGQYDAAAESWRKLQQALQAQIDADNENYSGYELTK
PSQ01752
FND00301
Trissin
Q4V645
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
52
G protein-coupled receptor binding
108
None
Trissin
7227
extracellular space
G protein-coupled receptor signaling pathway
21939639
52
57:108
RKRSDPDALRQSSNRRLIDFILLQGRALFTQELRERRHNGTLMDLGLNTYYP
PSQ01958
FND00240
Neuropeptide CCHamide-2
Q8SXL2
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
94
neuropeptide hormone activity
136
None
CCHa2
7227
extracellular space
neuropeptide signaling pathway
21214272, 23293632
94
43:136
SLSPGSGSGTGVGGGMGEAASGGQEPDYVRPNGLLPMMAPNEQVPLEGDFNDYPARQVLYKIMKSWFNRPRRPASRLGELDYPLANSAELNGVN
PSQ02081
FD00249
Serine protease 7
Q9V3Z2
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
109
metal ion binding, serine-type endopeptidase activity
391
Melanization protease 2
Sp7
7227
extracellular region, extracellular space
defense response to Gram-positive bacterium, melanization defense response, positive regulation of melanization defense response, proteolysis
24260243
109
28:136
QGSCRNPNQKQGQCLSIYDCQSLLSVIQQSYVSPEDRTFLRNSQCLDGVGRQPYVCCTSDRSFGSQEATSAAPPPTTTSSSSRGQDGQAGLGNLLPSPPKCGPHSFSNK
PSQ02082
FND00358
Neuropeptide F
Q9VET0
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
6, 37
G protein-coupled receptor binding, neuropeptide F receptor binding, neuropeptide hormone activity
102
dNPF
NPF
7227
extracellular region
circadian behavior, circadian rhythm, digestion, endocrine signaling, G protein-coupled receptor signaling pathway, larval feeding behavior, larval foraging behavior, larval locomotory behavior, locomotor rhythm, male courtship behavior, neuropeptide signaling pathway, olfactory behavior, regulation of response to food, response to odorant, social behavior
10499420;10499420
43
27:32, 66:102
SNSRPP, GSLMDILRNHEMDNINLGKNANNGGEFARGFNEEEIF
PSQ02083
FD00189
Serine protease HTRA2
Q9VFJ3
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
57
peptidase activity, serine-type endopeptidase activity
422
High temperature requirement protein A2 , Omi stress-regulated endoprotease
HtrA2
7227
cytosol, integral component of membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, Nebenkern
apoptotic process, ectopic germ cell programmed cell death, mitochondrion organization, positive regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity, regulation of apoptotic process, spermatogenesis
18259196
57
18:74
ASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLG
PSQ02084
FND00209
Protein hugin
Q9VG55
Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Holometabola Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila Sophophora
Drosophila melanogaster (Fruit fly)
95, 7
ecdysis-triggering hormone activity, hormone activity, myostimulatory hormone activity, neuropeptide receptor binding, signaling receptor binding
191
None
Hug
7227
extracellular region, extracellular space
ecdysis, chitin-based cuticle, larval feeding behavior, neuropeptide signaling pathway
12204246;12204246
102
25:119, 185:191
KSLQGTSKLDLGNHISAGSARGSLSPASPALSEARQKRAMGDYKELTDIIDELEENSLAQKASATMQVAAMPPQGQEFDLDTMPPLTYYLLLQKL, AQVCGGD